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Cachet, N.; Hoakwie, F.; Bertani, S.; Bourdy, G.; Deharo, E.; Stien, D.; Houel, E.; Gornitzka, H.; Fillaux, J.; Chevalley, S.; Valentin, A.; Jullian, V. |
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Title |
Antimalarial Activity of Simalikalactone E, a New Quassinoid from Quassia amara L. (Simaroubaceae) |
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Journal Article |
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2009 |
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Antimicrobial Agents and Chemotherapy |
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Antimicrob. Agents Chemother. |
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53 |
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10 |
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4393-4398 |
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We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered. |
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[Cachet, N.; Hoakwie, F.; Bourdy, G.; Deharo, E.; Chevalley, S.; Valentin, A.; Jullian, V.] Univ Toulouse, UPS, Lab Pharmacochim Subst Nat & Pharmacophores Redox, UMR 152, F-31062 Toulouse 9, France, Email: jullian@cict.fr |
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AMER SOC MICROBIOLOGY |
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0066-4804 |
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ISI:000270020600047 |
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103 |
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Cachet, N.; Ho-A-Kwie, F.; Rivaud, M.; Houel, E.; Deharo, E.; Bourdy, G.; Jullian, V. |
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Title |
Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae) |
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Journal Article |
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2012 |
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Phytochemistry Letters |
Abbreviated Journal |
Phytochem. Lett. |
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5 |
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1 |
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162-164 |
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Malaria; P. falciparum; Quassia amara; Quassinoids; Simaroubaceae |
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A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC 50 = 8 μM), and a similar low activity on human cancerous cells line (IC 50 = 7 μM on MCF-7 cells line). © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
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CNRS, UMR Ecofog, Université des Antilles et de la Guyane, Cayenne, France |
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18743900 (Issn) |
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Export Date: 8 March 2012; Source: Scopus; doi: 10.1016/j.phytol.2011.12.001; Language of Original Document: English; Correspondence Address: Jullian, V.; UMR-152 Pharma-Dev, IRD, Université Paul Sabatier Toulouse 3, 31062 Toulouse, France; email: jullian@cict.fr |
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382 |
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Boulogne, I.; Constantino, R.; Amusant, N.; Falkowski, M.; Rodrigues, A.M.S.; Houel, E. |
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Ecology of termites from the genus Nasutitermes (Termitidae: Nasutitermitinae) and potential for science-based development of sustainable pest management programs |
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2017 |
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Journal of Pest Science |
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Journal of Pest Science |
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90 |
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1 |
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19-37 |
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Antimicrobial and insecticidal botanical extracts; Ipm; Nasutitermes corniger; Sustainable management; Taxonomic history; Termitidae |
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The genus Nasutitermes is among the most abundant wood-feeding Termitidae and an extremely diverse and heterogeneous group in terms of its biogeography and morphology. Despite the major role of several Nasutitermes species as structural pests, the phylogenetic status of this genus is still unclear, along with a confused taxonomy and species identification remaining difficult. The first aim of this review was thus to gather and discuss studies concerning the taxonomic status of the genus Nasutitermes in order to clarify this crucial point. Then, our goal was to gain new insights into the management of N. corniger, considered to be the most economically detrimental pest of this genus in South America and a Nasutitermes model species, while filtering available information concerning its biology through the prism of termite control, as well as critically examine the existing methods. We indeed strongly believe that increasing our knowledge of this species’ biological strategies is the key to progress in the challenging question of their sustainable management. © 2016, Springer-Verlag Berlin Heidelberg. |
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Laboratoire de Biodiversité et Biotechnologies Microbiennes (LBBM), Observatoire Océanologique, Sorbonne Universités, Université Pierre et Marie Curie, CNRS, Banyuls/Mer, France |
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Export Date: 17 February 2017 |
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EcoFoG @ webmaster @ |
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732 |
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Bertani, S.; Houel, E.; Stien, D.; Chevolot, L.; Jullian, V.; Garavito, G.; Bourdy, G.; Deharo, E. |
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Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae) |
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2006 |
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Journal of Ethnopharmacology |
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J. Ethnopharmacol. |
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108 |
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1 |
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155-157 |
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antimalarial; Quassia amara; quassinoids; simalikalactone D; traditional medicine |
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French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
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Univ Toulouse 3, UMR 152, Ctr IRD, F-97323 Cayenne, French Guiana, Email: deharo@cayenne.ird.fr |
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ELSEVIER IRELAND LTD |
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0378-8741 |
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ISI:000241573000023 |
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EcoFoG @ eric.marcon @ |
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173 |
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Bertani, S.; Houel, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. |
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Title |
New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae) |
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Journal Article |
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2012 |
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Experimental Parasitology |
Abbreviated Journal |
Exp. Parasitol. |
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130 |
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4 |
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341-347 |
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Antimalarial; Plasmodium; Quassia amara; Quassinoid; Simalikalactone d |
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Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown to be one of the molecules responsible for the antiplasmodial activity of a watery preparation made out of juvenile fresh leaves of this plant. Because of its strong antimalarial activity, we decided to have a further insight of SkD pharmacological properties, alone or in association with classical antimalarials. At concentrations of up to 200 μM, we showed herein that SkD did not exert any apoptotic or necrotic activities in vitro on lymphoblastic cells. However, an antiproliferative effect was evident at concentrations higher than 45. nM. SkD was inefficient at inhibiting heme biomineralization and the new permeability pathways induced by the parasite in the host erythrocyte membrane. With respect to Plasmodium falciparum erythrocytic stages, SkD was almost inactive on earlier and later parasite stages, but potently active at the 30th h of parasite cycle when DNA replicates in mature trophozoites. In vitro combination studies with conventional antimalarial drugs showed that SkD synergizes with atovaquone (ATO). The activity of ATO on the Plasmodium mitochondrial membrane potential was enhanced by SkD, which on its own had a poor effect on this cellular parameter. © 2012 Elsevier Inc. |
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UMR152 IRD-UPS, Institut de Recherche pour le Développement (IRD), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru |
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00144894 (Issn) |
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Export Date: 24 April 2012; Source: Scopus; Coden: Expaa; doi: 10.1016/j.exppara.2012.02.013; Language of Original Document: English; Correspondence Address: Deharo, E.; UMR152 IRD-UPS, Faculté de Pharmacie, 35 chemin des maraîchers, 31062 Toulouse cedex 9, France; email: ericdeharo@gmail.com |
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EcoFoG @ webmaster @ |
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395 |
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