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Author (down) Bertani, S.; Houel, E.; Bourdy, G.; Stien, D.; Jullian, V.; Landau, I.; Deharo, E. openurl 
  Title Quassia amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation Type Journal Article
  Year 2007 Publication Journal of Ethnopharmacology Abbreviated Journal J. Ethnopharmacol.  
  Volume 111 Issue 1 Pages 40-42  
  Keywords antimalarial; Quassia amara; quassinoids; simalikalactone D; traditional medicine  
  Abstract In French Guiana, Quassia amara L. (Simaroubaceae) leaf tea is a well-known widely used traditional antimalarial remedy. Impact of the vegetal sampling condition on in vivo and in vitro antimalarial activity was assessed. Traditional infusions were prepared with juvenile or mature leaves, both either fresh or dried. Results showed that growing stage and freshness of vegetal material exert a striking effect on antimalarial activity, both in vitro and in vivo. By far, leaf tea made from fresh juvenile (FJ) Quassia amara leaves was the most active. In vitro, active component (simalikalactone D) concentration correlates biological activities, although unexplained subtle variations were observed. In vivo, tea made with dried juvenile (DJ) leaves displays a peculiar behavior, meaning that some components may help simalikalactone D delivery or may be active in vivo only, therefore enhancing the expected curative effect of the traditional preparation. (c) 2006 Elsevier Ireland Ltd. All rights reserved.  
  Address Univ Toulouse 3, Ctr IRD, UMR 152, IRD, F-97323 Cayenne Cx, Guyana, Email:  
  Corporate Author Thesis  
  Publisher ELSEVIER IRELAND LTD Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-8741 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000246059600007 Approved no  
  Call Number EcoFoG @ eric.marcon @ Serial 164  
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