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Author (up) Cachet, N.; Hoakwie, F.; Bertani, S.; Bourdy, G.; Deharo, E.; Stien, D.; Houel, E.; Gornitzka, H.; Fillaux, J.; Chevalley, S.; Valentin, A.; Jullian, V. openurl 
  Title Antimalarial Activity of Simalikalactone E, a New Quassinoid from Quassia amara L. (Simaroubaceae) Type Journal Article
  Year 2009 Publication Antimicrobial Agents and Chemotherapy Abbreviated Journal Antimicrob. Agents Chemother.  
  Volume 53 Issue 10 Pages 4393-4398  
  Keywords  
  Abstract We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.  
  Address [Cachet, N.; Hoakwie, F.; Bourdy, G.; Deharo, E.; Chevalley, S.; Valentin, A.; Jullian, V.] Univ Toulouse, UPS, Lab Pharmacochim Subst Nat & Pharmacophores Redox, UMR 152, F-31062 Toulouse 9, France, Email: jullian@cict.fr  
  Corporate Author Thesis  
  Publisher AMER SOC MICROBIOLOGY Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0066-4804 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000270020600047 Approved no  
  Call Number EcoFoG @ eric.marcon @ Serial 103  
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Author (up) Courtois, E.A.; Baraloto, C.; Timothy Paine, C.E.; Petronelli, P.; Blandinieres, P.-A.; Stien, D.; Houel, E.; Bessiere, J.-M.; Chave, J. doi  openurl
  Title Differences in volatile terpene composition between the bark and leaves of tropical tree species Type Journal Article
  Year 2012 Publication Phytochemistry Abbreviated Journal Phytochemistry  
  Volume 82 Issue Pages 81-88  
  Keywords French Guiana; Herbivory; Optimal defense theory; Secondary metabolites; Wood  
  Abstract Volatile terpenes are among the most diverse class of defensive compounds in plants, and they are implicated in both direct and indirect defense against herbivores. In terpenes, both the quantity and the diversity of compounds appear to increase the efficiency of defense as a diverse blend of compounds provides a more efficient protection against a broader range of herbivores and limits the chances that an enemy evolves resistance. Theory predicts that plant defensive compounds should be allocated differentially among tissues according to the value of the tissue, its cost of construction and the herbivore pressure on it. We collected volatile terpenes from bark and leaves of 178 individual tree belonging to 55 angiosperm species in French Guiana and compare the kind, amount, and diversity of compounds in these tissues. We hypothesized that in woody plants, the outermost part of the trunk should hold a more diverse blend of volatile terpenes. Additionally, as herbivore communities associated with the leaves is different to the one associated with the bark, we also hypothesized that terpene blends should be distinct in the bark vs. the leaves of a given species. We found that the mixture of volatile terpenes released by bark is different and more diverse than that released by leaves, both in monoterpenes and sesquiterpenes. This supports our hypothesis and further suggests that the emission of terpenes by the bark should be more important for trunk defense than previously thought.  
  Address Station d'Écologie Expérimentale du CNRS Moulis, USR 2936, 2 route du CNRS, 09200 Moulis, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 00319422 (Issn) ISBN Medium  
  Area Expedition Conference  
  Notes Export Date: 4 September 2012; Source: Scopus; Coden: Pytca; doi: 10.1016/j.phytochem.2012.07.003; Language of Original Document: English; Correspondence Address: Courtois, E.A.; Station d'Écologie Expérimentale du CNRS Moulis, USR 2936, 2 route du CNRS, 09200 Moulis, France; email: courtoiselodie@gmail.com Approved no  
  Call Number EcoFoG @ webmaster @ Serial 425  
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Author (up) Courtois, E.A.; Paine, C.E.T.; Blandinieres, P.A.; Stien, D.; Bessiere, J.M.; Houel, E.; Baraloto, C.; Chave, J. openurl 
  Title Diversity of the Volatile Organic Compounds Emitted by 55 Species of Tropical Trees: a Survey in French Guiana Type Journal Article
  Year 2009 Publication Journal of Chemical Ecology Abbreviated Journal J. Chem. Ecol.  
  Volume 35 Issue 11 Pages 1349-1362  
  Keywords VOCs; Chemical diversity; Sesquiterpenes; Tropical; French Guiana  
  Abstract Volatile organic compounds (VOCs) are produced by a broad range of organisms, from bacteria to mammals, and they represent a vast chemical diversity. In plants, one of the preeminent roles of VOCs is their repellent or cytotoxic activity, which helps the plant deter its predators. Most studies on VOCs emitted by vegetative parts have been conducted in model plant species, and little is known about patterns of VOC emissions in diverse plant communities. We conducted a survey of the VOCs released immediately after mechanical damage of the bark and the leaves of 195 individual trees belonging to 55 tropical tree species in a lowland rainforest of French Guiana. We discovered a remarkably high chemical diversity, with 264 distinct VOCs and a mean of 37 compounds per species. Two monoterpenes (alpha-pinene and limonene) and two sesquiterpenes (beta-caryophyllene and alpha-copaene), which are known to have cytotoxic and deterrent effects, were the most frequent compounds in the sampled species. As has been established for floral scents, the blend of VOCs is largely species-specific and could be used to discriminate among 43 of the 55 sampled species. The species with the most diverse blends were found in the Sapindales, Laurales, and Magnoliales, indicating that VOC diversity is not uniformly distributed among tropical species. Interspecific variation in chemical diversity was caused mostly by variation in sesquiterpenes. This study emphasizes three aspects of VOC emission by tropical tree species: the species-specificity of the mixtures, the importance of sesquiterpenes, and the wide-ranging complexity of the mixtures.  
  Address [Courtois, Elodie A.; Blandinieres, Pierre-Alain; Stien, Didier; Houel, Emeline] CNRS, UMR Ecofog, F-97337 Cayenne, France, Email: courtois@cict.fr  
  Corporate Author Thesis  
  Publisher SPRINGER Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0098-0331 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000273086100009 Approved no  
  Call Number EcoFoG @ eric.marcon @ Serial 73  
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Author (up) Diatta, Bétémondji Désiré ; Niass, Ousmane ; Diouf, Massamba ; Guéye, Mathieu ; Houel, Emeline ; Boetsch, Gilles doi  openurl
  Title Diversité et composition phytochimique des bâtonnets frotte-dents (cure-dents) proposés chez les Peul de la commune de Tessékéré (Ferlo Nord, Sénégal) Type Journal Article
  Year 2021 Publication Journal of Applied Biosciences Abbreviated Journal  
  Volume 158 Issue Pages 16267-16281  
  Keywords  
  Abstract Objectifs : Le but de cette étude était de déterminer la composition phytochimique et la teneur en grandes classes chimiques des tiges les plus utilisées comme bâtonnets frotte-dents chez les peul de Widou Thiengoli au Nord Ferlo (Sénégal). Méthodes et résultats : Des entretiens ouverts semi structurés ont permis de recueillir les plantes les plus utilisées. L’indice de fidélité renseigne sur la convergence des usages quant à l’emploi des plantes comme bâtonnets frotte-dent comparé aux autres pratiques cosmétiques. L’étude de la composition phytochimique des tiges a ciblé 8 classes chimiques. Les tanins et les saponines sont très fréquents ; les terpénoïdes et les leuco-anthocyanines presque inexistants. Un dosage des flavonoïdes, alcaloïdes et polyphénols, réalisé chez des extraits aqueux, a porté sur 12 plantes. Les meilleures teneurs en polyphénols et alcaloïdes sont recueillies chez Anogeissus leiocarpa, et la meilleure en flavonoïdes chez Commiphora africana. Conclusion et applicabilité des résultats : Ces résultats permettent de sélectionner à travers la composition phytochimique des plantes, les espèces présentant de potentielles activités antimicrobiennes, car renfermant des composés phytochimique doués de fonctions germicides, au- delà de la fonction mécanique connue des bâtonnets dans l’élimination de la plaque dentaire.  
  Address  
  Corporate Author Thesis  
  Publisher Elewa Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1997-5902 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number EcoFoG @ webmaster @ Serial 1053  
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Author (up) Falkowski, M.; Jahn-Oyac, A.; Ferrero, E.; Issaly, J.; Eparvier, V.; Girod, R.; Rodrigues, A.M.S.; Stien, D.; Houel, E.; Dusfour, I. pdf  url
doi  openurl
  Title Assessment of A Simple Compound-Saving Method to Study Insecticidal Activity of Natural Extracts and Pure Compounds Against Mosquito Larvae Type Journal Article
  Year 2016 Publication Journal of the American Mosquito Control Association Abbreviated Journal Journal of the American Mosquito Control Association  
  Volume 32 Issue 4 Pages 337-340  
  Keywords Mosquitoes; natural insecticides; screening method  
  Abstract Research on natural insecticides has intensified with the spread of resistance to chemicals among insects, particularly disease vectors. To evaluate compounds, the World Health Organization (WHO) has published standardized procedures. However, those may be excessively compound-consuming when it comes to assessing the activity of natural extracts and pure compounds isolated in limited amount. As part of our work on the discovery of new mosquito larvicides from Amazonian plants, we developed a compound-saving assay in 5-ml glass tubes instead of WHO larval 100-ml cups. Comparing activity of synthetic and natural chemicals validated the glass tube assay. Raw data, lethal doses that kill 50% (LD50) and 90% (LD90) at 24 and 48 h, were highly correlated (0.68 < R2 < 0.96, P < 0.001, Pearson test) between cups and tubes. It was also established that 10 tubes (N = 50 larvae) provided the same level of sensitivity as 20 tubes (N = 100). This method proved suitable for rapid screening of natural extracts and molecules, identifying active compounds using 10 times less material than in the WHO protocol. © 2016 by The American Mosquito Control Association, Inc.  
  Address Sorbonne Universites, UPMC, Universite Paris 06, CNRS, Laboratoire de Biodiversite et Biotechnologies Microbiennes (USR 3579, LBBM), Observatoire Oceanologique, avenue de Fontaul e, Banyuls/Mer-sur-mer, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Export Date: 3 March 2017 Approved no  
  Call Number EcoFoG @ webmaster @ Serial 740  
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