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Bertani, S.; Houel, E.; Stien, D.; Chevolot, L.; Jullian, V.; Garavito, G.; Bourdy, G.; Deharo, E. |
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Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae) |
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Journal Article |
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2006 |
Publication |
Journal of Ethnopharmacology |
Abbreviated Journal |
J. Ethnopharmacol. |
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108 |
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1 |
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155-157 |
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Keywords |
antimalarial; Quassia amara; quassinoids; simalikalactone D; traditional medicine |
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Abstract |
French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved. |
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Univ Toulouse 3, UMR 152, Ctr IRD, F-97323 Cayenne, French Guiana, Email: deharo@cayenne.ird.fr |
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ELSEVIER IRELAND LTD |
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0378-8741 |
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ISI:000241573000023 |
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EcoFoG @ eric.marcon @ |
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173 |
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Cachet, N.; Ho-A-Kwie, F.; Rivaud, M.; Houel, E.; Deharo, E.; Bourdy, G.; Jullian, V. |
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Picrasin K, a new quassinoid from Quassia amara L. (Simaroubaceae) |
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Journal Article |
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2012 |
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Phytochemistry Letters |
Abbreviated Journal |
Phytochem. Lett. |
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5 |
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1 |
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162-164 |
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Keywords |
Malaria; P. falciparum; Quassia amara; Quassinoids; Simaroubaceae |
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A new quassinoid Picrasin K 1 was isolated from a decoction made of Quassia amara leaves, traditionally used in French Guyana to treat malaria. The structure and relative stereochemistry of 1 was determined through extensive NMR analysis. Picrasin K showed a low activity against Plasmodium falciparum in vitro (IC 50 = 8 μM), and a similar low activity on human cancerous cells line (IC 50 = 7 μM on MCF-7 cells line). © 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. |
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CNRS, UMR Ecofog, Université des Antilles et de la Guyane, Cayenne, France |
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18743900 (Issn) |
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Export Date: 8 March 2012; Source: Scopus; doi: 10.1016/j.phytol.2011.12.001; Language of Original Document: English; Correspondence Address: Jullian, V.; UMR-152 Pharma-Dev, IRD, Université Paul Sabatier Toulouse 3, 31062 Toulouse, France; email: jullian@cict.fr |
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EcoFoG @ webmaster @ |
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382 |
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Bertani, S.; Houel, E.; Jullian, V.; Bourdy, G.; Valentin, A.; Stien, D.; Deharo, E. |
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New findings on Simalikalactone D, an antimalarial compound from Quassia amara L. (Simaroubaceae) |
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Journal Article |
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2012 |
Publication |
Experimental Parasitology |
Abbreviated Journal |
Exp. Parasitol. |
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130 |
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4 |
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341-347 |
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Keywords |
Antimalarial; Plasmodium; Quassia amara; Quassinoid; Simalikalactone d |
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Quassia amara L. (Simaroubaceae) is a species widely used as tonic and is claimed to be an efficient antimalarial all over the Northern part of the Amazon basin. Quassinoid compound Simalikalactone D (SkD) has been shown to be one of the molecules responsible for the antiplasmodial activity of a watery preparation made out of juvenile fresh leaves of this plant. Because of its strong antimalarial activity, we decided to have a further insight of SkD pharmacological properties, alone or in association with classical antimalarials. At concentrations of up to 200 μM, we showed herein that SkD did not exert any apoptotic or necrotic activities in vitro on lymphoblastic cells. However, an antiproliferative effect was evident at concentrations higher than 45. nM. SkD was inefficient at inhibiting heme biomineralization and the new permeability pathways induced by the parasite in the host erythrocyte membrane. With respect to Plasmodium falciparum erythrocytic stages, SkD was almost inactive on earlier and later parasite stages, but potently active at the 30th h of parasite cycle when DNA replicates in mature trophozoites. In vitro combination studies with conventional antimalarial drugs showed that SkD synergizes with atovaquone (ATO). The activity of ATO on the Plasmodium mitochondrial membrane potential was enhanced by SkD, which on its own had a poor effect on this cellular parameter. © 2012 Elsevier Inc. |
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UMR152 IRD-UPS, Institut de Recherche pour le Développement (IRD), Universidad Peruana Cayetano Heredia (UPCH), Lima, Peru |
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00144894 (Issn) |
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Export Date: 24 April 2012; Source: Scopus; Coden: Expaa; doi: 10.1016/j.exppara.2012.02.013; Language of Original Document: English; Correspondence Address: Deharo, E.; UMR152 IRD-UPS, Faculté de Pharmacie, 35 chemin des maraîchers, 31062 Toulouse cedex 9, France; email: ericdeharo@gmail.com |
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EcoFoG @ webmaster @ |
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395 |
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Courtois, E.A.; Baraloto, C.; Timothy Paine, C.E.; Petronelli, P.; Blandinieres, P.-A.; Stien, D.; Houel, E.; Bessiere, J.-M.; Chave, J. |
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Differences in volatile terpene composition between the bark and leaves of tropical tree species |
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Journal Article |
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2012 |
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Phytochemistry |
Abbreviated Journal |
Phytochemistry |
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82 |
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81-88 |
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French Guiana; Herbivory; Optimal defense theory; Secondary metabolites; Wood |
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Volatile terpenes are among the most diverse class of defensive compounds in plants, and they are implicated in both direct and indirect defense against herbivores. In terpenes, both the quantity and the diversity of compounds appear to increase the efficiency of defense as a diverse blend of compounds provides a more efficient protection against a broader range of herbivores and limits the chances that an enemy evolves resistance. Theory predicts that plant defensive compounds should be allocated differentially among tissues according to the value of the tissue, its cost of construction and the herbivore pressure on it. We collected volatile terpenes from bark and leaves of 178 individual tree belonging to 55 angiosperm species in French Guiana and compare the kind, amount, and diversity of compounds in these tissues. We hypothesized that in woody plants, the outermost part of the trunk should hold a more diverse blend of volatile terpenes. Additionally, as herbivore communities associated with the leaves is different to the one associated with the bark, we also hypothesized that terpene blends should be distinct in the bark vs. the leaves of a given species. We found that the mixture of volatile terpenes released by bark is different and more diverse than that released by leaves, both in monoterpenes and sesquiterpenes. This supports our hypothesis and further suggests that the emission of terpenes by the bark should be more important for trunk defense than previously thought. |
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Station d'Écologie Expérimentale du CNRS Moulis, USR 2936, 2 route du CNRS, 09200 Moulis, France |
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00319422 (Issn) |
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Export Date: 4 September 2012; Source: Scopus; Coden: Pytca; doi: 10.1016/j.phytochem.2012.07.003; Language of Original Document: English; Correspondence Address: Courtois, E.A.; Station d'Écologie Expérimentale du CNRS Moulis, USR 2936, 2 route du CNRS, 09200 Moulis, France; email: courtoiselodie@gmail.com |
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EcoFoG @ webmaster @ |
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425 |
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Houel, E.; Rodrigues, A.M.S.; Jahn-Oyac, A.; Bessière, J.-M.; Eparvier, V.; Deharo, E.; Stien, D. |
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In vitro antidermatophytic activity of Otacanthus azureus (Linden) Ronse essential oil alone and in combination with azoles |
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2014 |
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Journal of Applied Microbiology |
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J. Appl. Microbiol. |
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116 |
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2 |
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288-294 |
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Antifungal activity; Azoles; Dermatophytes; Essential oil; Otacanthus azureus; Synergy |
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Aims: We determined the chemical composition and investigated the antifungal activity of Otacanthus azureus (Linden) Ronse essential oil (EO) against a range of dermatophytes alone or in combination with azole antifungals. Methods and Results: Aerial parts of the plant were steam-distilled and the obtained oil was analysed by gas chromatography/mass spectrometry and 1H-NMR. It was shown to be largely composed of sesquiterpenes, with the main component being β-copaen-4-α-ol. Using broth microdilution techniques, this oil was found to have remarkable in vitro antifungal activities. Minimum inhibitory concentrations as low as 4 μg ml-1 were recorded. The analysis of the combined effect of the O. azureus EO with azoles using chequerboard assays revealed a synergism between the EO and ketoconazole, fluconazole or itraconazole against Trichophyton mentagrophytes. Notably, the O. azureus essential oil showed low cytotoxicity to VERO cells. Conclusions: The O. azureus essential oil alone or in combination with azoles is a promising antifungal agent in the treatment for human dermatomycoses caused by filamentous fungi. Significance and Impact of the Study: There is much interest in the study of essential oils for the discovery of new antimicrobial drugs. This study has highlighted the antidermatophytic activity of the O. azureus EO. © 2013 The Society for Applied Microbiology. |
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Institut de Recherche pour le Développement (IRD), UMR 152 Pharma-DEV, Toulouse, France |
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13645072 (Issn) |
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Export Date: 9 February 2014; Source: Scopus; Coden: Jamif; Language of Original Document: English; Correspondence Address: Houël, E.; CNRS – UMR Ecologie des Forêts de Guyane (EcoFoG), Institut Pasteur de la Guyane, 23 Avenue Pasteur, BP6010, 97306 Cayenne Cedex, French Guiana; email: emeline.houel@ecofog.gf |
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EcoFoG @ webmaster @ |
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526 |
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