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Author Cachet, N.; Hoakwie, F.; Bertani, S.; Bourdy, G.; Deharo, E.; Stien, D.; Houel, E.; Gornitzka, H.; Fillaux, J.; Chevalley, S.; Valentin, A.; Jullian, V. openurl 
  Title Antimalarial Activity of Simalikalactone E, a New Quassinoid from Quassia amara L. (Simaroubaceae) Type (up) Journal Article
  Year 2009 Publication Antimicrobial Agents and Chemotherapy Abbreviated Journal Antimicrob. Agents Chemother.  
  Volume 53 Issue 10 Pages 4393-4398  
  Abstract We report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.  
  Address [Cachet, N.; Hoakwie, F.; Bourdy, G.; Deharo, E.; Chevalley, S.; Valentin, A.; Jullian, V.] Univ Toulouse, UPS, Lab Pharmacochim Subst Nat & Pharmacophores Redox, UMR 152, F-31062 Toulouse 9, France, Email:  
  Corporate Author Thesis  
  Publisher AMER SOC MICROBIOLOGY Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0066-4804 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000270020600047 Approved no  
  Call Number EcoFoG @ eric.marcon @ Serial 103  
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