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Author Bertani, S.; Houel, E.; Stien, D.; Chevolot, L.; Jullian, V.; Garavito, G.; Bourdy, G.; Deharo, E. openurl 
  Title Simalikalactone D is responsible for the antimalarial properties of an amazonian traditional remedy made with Quassia amara L. (Simaroubaceae) Type Journal Article
  Year 2006 Publication Journal of Ethnopharmacology Abbreviated Journal J. Ethnopharmacol.  
  Volume 108 Issue 1 Pages 155-157  
  Keywords antimalarial; Quassia amara; quassinoids; simalikalactone D; traditional medicine  
  Abstract French Guiana (North-East Amazonia) records high malaria incidence rates. The traditional antimalarial remedy most widespread there is a simple tea made out from Quassia amara L. leaves (Simaroubaceae). This herbal tea displays an excellent antimalarial activity both in vitro and in vivo. A known quassinoid, simalikalactone D (SkD), was identified as the active compound, with an IC50 value of 10 nM against FeB1 Plasmodium falciparum chloroquine resistant strain in vitro. Lastly, it inhibits 50% of Plasmodium yoelii yoelii rodent malaria parasite at 3.7 mg/kg/day in vivo by oral route. These findings confirm the traditional use of this herbal tea. (c) 2006 Elsevier Ireland Ltd. All rights reserved.  
  Address Univ Toulouse 3, UMR 152, Ctr IRD, F-97323 Cayenne, French Guiana, Email:  
  Corporate Author Thesis  
  Publisher ELSEVIER IRELAND LTD Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-8741 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000241573000023 Approved no  
  Call Number EcoFoG @ eric.marcon @ Serial (down) 173  
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