toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
  Record Links
Author (up) Houel, E.; Rodrigues, A.M.S.; Jahn-Oyac, A.; Bessière, J.-M.; Eparvier, V.; Deharo, E.; Stien, D. url  openurl
  Title In vitro antidermatophytic activity of Otacanthus azureus (Linden) Ronse essential oil alone and in combination with azoles Type Journal Article
  Year 2014 Publication Journal of Applied Microbiology Abbreviated Journal J. Appl. Microbiol.  
  Volume 116 Issue 2 Pages 288-294  
  Keywords Antifungal activity; Azoles; Dermatophytes; Essential oil; Otacanthus azureus; Synergy  
  Abstract Aims: We determined the chemical composition and investigated the antifungal activity of Otacanthus azureus (Linden) Ronse essential oil (EO) against a range of dermatophytes alone or in combination with azole antifungals. Methods and Results: Aerial parts of the plant were steam-distilled and the obtained oil was analysed by gas chromatography/mass spectrometry and 1H-NMR. It was shown to be largely composed of sesquiterpenes, with the main component being β-copaen-4-α-ol. Using broth microdilution techniques, this oil was found to have remarkable in vitro antifungal activities. Minimum inhibitory concentrations as low as 4 μg ml-1 were recorded. The analysis of the combined effect of the O. azureus EO with azoles using chequerboard assays revealed a synergism between the EO and ketoconazole, fluconazole or itraconazole against Trichophyton mentagrophytes. Notably, the O. azureus essential oil showed low cytotoxicity to VERO cells. Conclusions: The O. azureus essential oil alone or in combination with azoles is a promising antifungal agent in the treatment for human dermatomycoses caused by filamentous fungi. Significance and Impact of the Study: There is much interest in the study of essential oils for the discovery of new antimicrobial drugs. This study has highlighted the antidermatophytic activity of the O. azureus EO. © 2013 The Society for Applied Microbiology.  
  Address Institut de Recherche pour le Développement (IRD), UMR 152 Pharma-DEV, Toulouse, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 13645072 (Issn) ISBN Medium  
  Area Expedition Conference  
  Notes Export Date: 9 February 2014; Source: Scopus; Coden: Jamif; Language of Original Document: English; Correspondence Address: Houël, E.; CNRS – UMR Ecologie des Forêts de Guyane (EcoFoG), Institut Pasteur de la Guyane, 23 Avenue Pasteur, BP6010, 97306 Cayenne Cedex, French Guiana; email: Approved no  
  Call Number EcoFoG @ webmaster @ Serial 526  
Permanent link to this record
Select All    Deselect All
 |   | 

Save Citations:
Export Records: