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Author (up) Houel, E.; Bertani, S.; Bourdy, G.; Deharo, E.; Jullian, V.; Valentin, A.; Chevalley, S.; Stien, D. openurl 
  Title Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity Type Journal Article
  Year 2009 Publication Journal of Ethnopharmacology Abbreviated Journal J. Ethnopharmacol.  
  Volume 126 Issue 1 Pages 114-118  
  Keywords Quassia amara L.; Simaroubaceae; Leaf tea; Antimalarial activity; Cytotoxicity; Simalikalactone D  
  Abstract Aim of the study: Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria. and if yes. set up a standard protocol for preparing the herbal tea. Materials and methods: The leaf tea was extracted with methylene chloride and the organic extract was fractionated with HPLC. Pure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined. Results and discussion: We discovered that antimalarial Quassia amara young leaf tea contains several quassinoids: simalikalactone D (SkD. 1), picrasin B (2). picrasin H (3), neoquassin (4), quassin (5), picrasin 1(6) and picrasin J (7). These last two compounds are new. In addition. our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD. Conclusion: In conclusion, this preparation Should not be recommended for treatment of malaria until a clinical Study in humans is performed with SkD. (C) 2009 Elsevier Ireland Ltd. All rights reserved  
  Address [Stien, Didier] Univ Antilles Guyane, CNRS, UMR Ecofog, Inst Enseignement Super Guyane, F-97337 Cayenne, France, Email:  
  Corporate Author Thesis  
  Publisher ELSEVIER IRELAND LTD Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-8741 ISBN Medium  
  Area Expedition Conference  
  Notes ISI:000271790800015 Approved no  
  Call Number EcoFoG @ eric.marcon @ Serial 94  
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